In vitro effects of newly synthesized propane sulfonyl hydrazone derivatives on rat myometrial contractions

ŞUMLU, Esra | ÖZDEMİR ÖZMEN, Ummuhan | ÇALIŞKAN SAK, Kaniye Zeynep | YAVUZ, Ayça | BİLEN AYAN, Esra | KUTLU, Selim

This study aimed to investigate the potential of newly synthesized sulfonyl hydrazone (SH) derivatives to modulate contractions in isolated rat myometrium. For this purpose, the structures of SH compounds were characterized by elemental analyses and spectroscopic methods. Virgin female rats were obtained from KONUDAM Experimental Animal Research Centre (Konya, Turkey). Longitudinal myometrial strips, rapidly isolated post-decapitation, were rapidly inserted into a tissue bath containing Krebs' solution to monitor spontaneous contractions. Separate strips from each rat were treated with two dif ...Daha fazlası