Effects of Mu Opioidergic Receptors on Endoplasmic Reticulum Stress in the Hypothalamus on Rats

ŞEN, Aysu | EROĞLU GÜNEŞ, Canan | ÇALIŞKAN SAK, Kaniye Zeynep | ERKAYA, Zeliha | DURSUN, Ebru Nur | KURAR, Ercan | KUTLU, Selim

AIM: Morphine, has strong analgesic effect as mu opioid receptor agonist. Naloxone is widely used as a general opioid receptorantagonist in many scientific researches. The effect of mu opioidergic effect on endoplasmic reticulum stress (ERS) in thehypothalamus is unknown. The aim of this study was to investigate the possible effects of morphine and naloxone on ERSmarkers in rat hypothalamus. METHODS: In the study, 24 young adult male Wistar albino rats were used. Animals were divided into 4 groups as control groupadministered wehicle for 5 days, morphine group administered 10mg/kg/day morphine ...Daha fazlası