The Effect of Melatonin and Zinc Application in Rats Induced Mammary Carcinoma with DMBA on Lipid Peroxidation

GÜLBAHÇE MUTLU, Elif | MENEVŞE, Esma | BALTACI, Abdülkerim Kasım | MOĞULKOÇ, Rasim

Mammary cancer, which is the second most common cause of cancer deaths, is one of the problems of global public health. It is argued that anti estrogenic agents such as melatonin will lead to a new aspect in treatment of breast cancer. In addition, zinc, which plays a crucial role in the etiology of cancer, is vital for many cellular processes, and an important trace mineral. Trace elements are regarded as multiple anti-cancer agents that regulate various biological mechanisms. METHODS: In this study, it was aimed to investigate the effects of melatonin and zinc application on lipid peroxidati ...Daha fazlası

Mcf-7 Hücre hattında Üzüm (Vitis Vinifera L.) Çekirdeği Ekstraktının Sitotoksik Etkisinin Belirlenmesi

KOYGUN, Gözde | ARSLAN, Emine | GÜLBAHÇE MUTLU, Elif

Giriş: Kanser, hücre mitozunu kontrol eden genlerin mutasyona uğraması sonucunda hücrelerin kontrolsüz, aşırı ve hızlı bir şekilde çoğalmasına neden olan sistemik bir hastalıktır. Dünya çapındaki tüm yeni kanser teşhislerinin yaklaşık onda birini oluşturan meme kanseri ise, kadınlarda en sık görülen kanser tümörüdür. Metastaz yapma yeteneğine sahip olan tüm kanser hücreleri zamanla bütün organlara yayılabilmektedir. Kanser tedavisinde kullanılan kemoterapötik ilaçların yan etkileri de oldukça fazladır ve bu ilaçlar kanserli hücrelerin yanı sıra sağlıklı hücreleri de etkilemektedir. Bu nedenle ...Daha fazlası

Protective Effect of Melatonin in the Diabetic Elderly Female Rats Retinal

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | DAŞDELEN, Derviş | ÜNAL, Ömer | MOĞULKOÇ, Rasim | BALTACI, Saltuk Buğra

This study was designed to evaluate the efficacy of melatonin against streptozotocin (STZ)‐induced changes in rat retina following the development of diabetes. The study was performed on elderly female rats (16 months) obtained from Selçuk University Experimental Medicine Research and Application Center. The ethics committee of the same center approved the study. A total of 24 elderly female rats were divided into 4 groups. Group 1. Control, Group 2. Control + Melatonin Group 3. Diabetes, Group 4. Diabetes + Melatonin. Experimental diabetes was induced to Group 3 and group 4 by a single intrap ...Daha fazlası

The Effects of Resveratrol Supplementation on Oxidant Stress in Old Female Rats with Induced Diabetes

ATACAK, Adem | GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | ÜNAL, Ömer | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

Bu çalışmanın amacı diyabet oluşturulmuş yaşlı dişi sıçan modelinde resveratrol desteğinin retinal doku hasarını nasıl etkilediğini araştırmaktır. Bu çalışma Selçuk Üniversitesi Deneysel Tıp Araştırma ve Uygulama Merkezinden temin edilen Wistar cinsi 24 adet erişkin yaşlı dişi sıçan (16 haftalık) üzerinde aynı merkezde gerçekleştirildi. Çalışma protokolü Selçuk Üniversitesi Deneysel Tıp Araştırma ve Uygulama Merkezi Deney Hayvanları Etik Kurulu tarafından onaylandı. Toplam 24 adet yaşlı dişi sıçan kullanılan araştırmada gruplar şu şekilde oluşturuldu: Grup 1. Kontrol, Grup 2. Kontrol + resvera ...Daha fazlası

Antioxidant and antimicrobial activity of Mespilus germanica (L.)

GÜLBAHÇE MUTLU, Elif | TANER SARAÇOĞLU, Hatice | ARSLAN, Nursena | ARSLAN, Emine | ZENGİN, Gökhan

Mespilus germanica L. which has an edible fruit is a medicinal plant whose therapeutic effects have historically been emphasized. In this study, we determined antioxidant capacities of methanolic extracts obtained from M. germanica fruits and seeds by using DPPH assay and Folin-Ciocaltaeu method. It was revealed that the total phenolic contents of methanolic extracts of M. germanica seeds (22.94 mgGAE/g extract) were higher than M. germanica fruits (4.67 mgGAE/g extract). Also, the seed extract (9.33 mgTE/g extract) exhibited stronger free radical scavenging activity in DPPH assay as compared ...Daha fazlası

Effects of Soybean Seed (Glycine max) on Some Biochemical Parameters in Streptozotocin- Induced Daibetic Rats

GÜLBAHÇE MUTLU, Elif | ARSLAN, Emine | ARIKOĞLU, Hilal | ERKOÇ KAYA, Dudu

Introduction: Diabetes mellitus is the most widespread and increasingly global prevalence and incidence, and is a chronic metabolic disorder resulting from insulin deficiency or insulin insufficiency. A consequence of this is chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. In this study, soybean (Glycine max L.) seed extract in wistar rats created experimentally diabetic was aimed to investigate of the effects to some biochemical parameters (Urea, Creatinine, AST, ALT, Cholesterol, Triglycerides, Glucose, LDL, HDL, VLDL) and hyperglycemia. Material and Met ...Daha fazlası

Cerebral Ischemia Reperfusion Injury in Rats: Effect of 3’,4’-Dihydroxyflavonol

MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım | MENEVŞE, Esma | BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif

The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA level ...Daha fazlası

Bozkır Ağaç sincabının (Sciurus anomalus) diğer Sciurus türleri arasındaki Filogenetik akrabalığının belirlenmesi

GÜLBAHÇE MUTLU, Elif | ARSLAN, Emine | ARSLAN, Atilla

Kemiriciler (Rodentia) dünyadaki mevcut memeliler arasında en büyük grubu oluşturmaktadırlar ve kendi aralarında taksonomik ve filogenetik sınıflandırılması oldukça önemlidir. Sciurus cinsi, Rodentia takımı içerisinde yer alan Sciuridae (Sincapgiller) familyasının üyelerindendir. Türkiye’de Sciurus anomalus ve Sciurus vulgaris türleri yayılış göstermektedir. Bu çalışmada Konya ili Bozkır ilçesinden elde edilen S. anomalus türü ile Gen Bankası (NCBI)’ndan elde edilen Sciurus türleri arasında filogenetik akrabalıkların mitokondrial sitokrom b gen dizileri kullanılarak belirlenmesi amaçlanmıştır. ...Daha fazlası

Determination of relationship degrees according to protein profiles of some fish species living in Beyşehir, Suğla Lake and Dam Apa and investigation of the effect on protein profiles of seasonal temperature changes in some fish species

ARSLAN, Emine | GÜLBAHÇE MUTLU, Elif

Comparisons based on morphological characters is not enough for making the right decision in the determination of the species of taxonomists. Electrophoretic methods are frequently used by animal systematics in taxonomic studies. Proteins are the product of gene effect and are used as genetic markers that play an important role in determining the taxonomic status. In recent years, electrophoretic investigation of proteins has contributed both to the systematic studies and to the studies done on the biochemistry of fish. As well as determining degrees of relationship among fish that are collect ...Daha fazlası

The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MENEVŞE, Esma | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

In this study, it was aimed to investigate the effects of application of melatonin and zinc on lipid peroxidation and elemental metabolism in female rats with DMBA-induced mammary carcinoma. The study groups were composed of control, DMBA control and treatment (DMBA+ zinc, DMBA + melatonin and DMBA + zinc+melatonin) groups. Female rats (except the control group) were given a strong carcinogen DMBA. After tumour formation, zinc and melatonin were administered to the treatment groups at a dose of 5 mg/kg/day for 4 weeks. MDA as an indicator of tissue damage and GSH levels as an indicator of anti ...Daha fazlası

Kronik Yüzme Egzersizi Yaptırılan ve Grape Uygulanmış Epileptik Sıçanların Beyin Dokusundaki Element Dağılımı

AĞAR, Erdal | TUTKUN, Erkut | GÜLBAHÇE MUTLU, Elif | AYYILDIZ, Mustafa | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

Increased IL-6 Levels Inhibites by Zinc and Melatonin Support in Rats with Breast Cancer induced by DMBA

BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of the present study determines the effect of zinc and melatonin supplementation on IL-6 levels in female rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 wistar female rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA+Melatonin, Group 5 DMBA+Zinc+Melatonin. To induce breast cancer, the animals, except those in group 1, were administered 80 mg/kg of DMBA in colza oil (canola) through gavage. The groups which were supplemented with zinc and melatonin were introperitone ...Daha fazlası